$ QT_DEBUG_PLUGINS=1 ./nuxeo-drive-4.1.4-x86_64.AppImage Cannot load library crypto: (crypto: cannot open shared object file: No such file or directory) loaded library "crypto" loaded library "ssl" qt.network.ssl: QSslSocket: cannot resolve CRYPTO_num_locks qt.network.ssl: QSslSocket: cannot resolve CRYPTO_set_id_callback qt.network.ssl: QSslSocket: cannot resolve CRYPTO_set_locking_callback qt.network.ssl: QSslSocket: cannot resolve ERR_free_strings qt.network.ssl: QSslSocket: cannot resolve EVP_CIPHER_CTX_cleanup qt.network.ssl: QSslSocket: cannot resolve EVP_CIPHER_CTX_init qt.network.ssl: QSslSocket: cannot resolve sk_new_null qt.network.ssl: QSslSocket: cannot resolve sk_push qt.network.ssl: QSslSocket: cannot resolve sk_free qt.network.ssl: QSslSocket: cannot resolve sk_num qt.network.ssl: QSslSocket: cannot resolve sk_pop_free qt.network.ssl: QSslSocket: cannot resolve sk_value qt.network.ssl: QSslSocket: cannot resolve SSL_library_init qt.network.ssl: QSslSocket: cannot resolve SSL_load_error_strings qt.network.ssl: QSslSocket: cannot resolve SSL_get_ex_new_index qt.network.ssl: QSslSocket: cannot resolve SSLv3_client_method qt.network.ssl: QSslSocket: cannot resolve SSLv23_client_method qt.network.ssl: QSslSocket: cannot resolve SSLv3_server_method qt.network.ssl: QSslSocket: cannot resolve SSLv23_server_method qt.network.ssl: QSslSocket: cannot resolve X509_STORE_CTX_get_chain qt.network.ssl: QSslSocket: cannot resolve OPENSSL_add_all_algorithms_noconf qt.network.ssl: QSslSocket: cannot resolve OPENSSL_add_all_algorithms_conf qt.network.ssl: QSslSocket: cannot resolve SSLeay qt.network.ssl: Incompatible version of OpenSSL
This is a mismatch between OpenSSL 1.0.x and 1.1.y used between Qt <> Python and the OS.
I think upgrading to PyQt 5.12 will fix it.