In this documentation: https://doc.nuxeo.com/nxdoc/amazon-s3-online-storage/#specifying-your-amazon-s3-parameters
need to update the binary manager used to be
nuxeo.core.binarymanager=org.nuxeo.ecm.blob.s3.S3BlobProvider
This should be added to nuxeo.conf regardless of how you installed the package.
Update documentation for 10.10 and LTS2021.